Find out more about the gas mileage of the Mercedes-Benz E 350 for 2022 at Mercedes-Benz of Boerne.
The 2022 Mercedes-Benz E 350 is one more crown jewel from the E-Class series of Mercedes-Benz. The 2022 E 350 is available in two models; the base E 350 and the E 350 4MATIC®. Every year the E-Class Sedan advances the standards for all cars to follow, from luxury, safety, and driver-assist technology to less time at the gas pump. Boasting newly enhanced innovations in a new way like the Mercedes-Benz built-in Emergency Call Service, the 2022 Mercedes-Benz E 350 is the next generation of luxury today.
READ MORE: What is EPA MPG?
| Miles Per Gallon of the 2022 Mercedes-Benz E 350 | ||||
|---|---|---|---|---|
| Trim Levels | MPG | Gas Tank Size | Engine Specs | |
| E 350 4MATIC® | 23 City, 30 Highway | 17.4 Gallons | 255 Horsepower, 2.0L Turbocharged 4-cylinder | |
| E 350 | 23 City, 31 Highway | 17.4 Gallons | 255 Horsepower, 2.0L Turbocharged 4-cylinder | |
The brand-new Mercedes-Benz E 350 has a 17.4-gallon gas tank size for both the base E 350 and E 350 4MATIC® models. When you combine this ample gasoline tank size with the ECO-START® system, you get more out of the fuel tank. Plus, there are four different driving modes: ECO, Comfort, Sport, and Sport+ to customize the E 350 however you want.
The 2022 Mercedes-Benz E 350 should have more than 530 miles of max range on a single tank of gas. This comes from the estimated mileage numbers of the base E 350, which is expected to return 23 city mpg and 31 highway mpg, which makes for a combined 27mpg. In comparison, the 4MATIC® model is expected to get 21 city miles per gallon and 29 highway mpg, making for a combined 25mpg. No matter what model you select, you’re going to get a lot from the new 2022 Mercedes-Benz E 350.
The new Mercedes-Benz E 350 is equipped with a 2.0-liter turbo 4-cylinder engine for the standard and optional 4MATIC® trim level. A 9G-TRONIC 9-speed automatic is equipped in both options. The base E 350 utilizes RWD, while the E 350 4MATIC® uses 4MATIC® all-wheel drive. The 2022 E 350 engine will take you from 0-60 in 6 seconds, while the E 350 4MATIC® comes in at 6 seconds flat. Both trim levels create 255 hp and 273 lb.-ft. of torque. If you’re in the market for the next-gen of luxury vehicles, the 2022 Mercedes-Benz E 350 is the sedan you’ve been waiting for.
Learn more about the 2022 E 350 at our Mercedes-Benz dealership near San Antonio. Visit us in person or online to schedule your test drive. Our helpful staff is standing by to help you get into the luxury car or SUV of your dreams.
Descubre el Mercedes-Benz E 350 cerca de San Antonio, TX. Si, se habla español. Visítanos hoy.
2022 Mercedes-Benz E 350 MPG | Mercedes-Benz of Boerne
The sales team is terrific! The facility is clean and very relaxing for a dealership. Unfortunately, we had an issue with a service advisor named Paco. He was not polite and argued with us about the request we made that was part of the reason we brought the car for service. He didn’t want to help us any further and told us to go talk to ‘sales’ because he refused to do the work we asked, thank god our terrific sales guy Francisco helped us and got the part we needed!! Sales dept gets an A+ the service dept ... Read More Full review text opened.DealerRater - Jun 30, 2026
The sales team is terrific! The facility is clean and very relaxing for a dealership. Unfortunately, we had an issue with a service advisor named Paco. He was not polite and argued with us about the request we made that was part of the reason we brought the car for service. He didn’t want to help us any further and told us to go talk to ‘sales’ because he refused to do the work we asked, thank god our terrific sales guy Francisco helped us and got the part we needed!! Sales dept gets an A+ the service dept gets an F!
Thi is not my first trip to the Mercedes-Benz service center but another seemless service event. Ms Linda De La Cruz was her usual wonderful self. So helpful and informative. Love her consistency over the years.
Great service. Attention to detail, kept me updated about the process and price transparency. Highly recommended.
Great customer service. Was never pressured advised all the corrections got what I needed in and out thank you.
The best service ever .,everyone was helpful, courteous and went out of their way to see that I was made comfortable
